The widely used diabetes
drug metformin comes with a rather unexpected and alluring side effect: it
encourages the growth of new neurons in the brain. The study reported in the
July 6th issue of Cell Stem Cell also finds that those neural effects of the
drug also make mice smarter.
The discovery is an important step toward therapies that
aim to repair the brain not by introducing new stem cells but rather by
spurring those that are already present into action, says the study's lead
author Freda Miller of the University of Toronto-affiliated Hospital for Sick
Children. The fact that it's a drug that is so widely used and so safe makes
the news all that much better.
Earlier work by Miller's team highlighted a pathway known
as aPKC-CBP for its essential role in telling neural stem cells where
and when to differentiate into mature neurons. As it happened, others had found
before them that the same pathway is important for the metabolic effects of the
drug metformin, but in liver
cells.
"We put two and two together," Miller says. If
metformin activates the CBP pathway in the liver, they thought, maybe it could
also do that in neural stem cells of the brain to encourage brain repair.
The new evidence lends support to that promising idea in
both mouse brains and human
cells. Mice taking metformin not only showed an increase in the birth of
new neurons, but they were also better able to learn the location of a hidden
platform in a standard maze test of spatial learning.
While it remains to be seen whether the very
popular diabetes
drug might already be serving as a brain booster for those who are now
taking it, there are already some early hints that it may have cognitive benefits for
people with Alzheimer's disease. It had been thought those improvements were
the result of better diabetes control,
Miller says, but it now appears that metformin may improve Alzheimer's symptoms
by enhancing brain repair.
Miller says they now hope to test whether metformin might
help repair the brains of those who have suffered brain injury due to trauma or
radiation therapies for cancer.
More information: Wang et al.:
"Metformin activates an atypical PKC-CBP pathway to promote neurogenesis
and enhance spatial memory formation."Cell Stem Cell,
DOI:10.1016/j.stem.2012.03.016
Abstract
Although endogenous recruitment of adult neural stem cells has been proposed as a therapeutic strategy, clinical approaches for achieving this are lacking. Here, we show that metformin, a widely used drug, promotes neurogenesis and enhances spatial memory formation. Specifically, we show that an atypical PKC-CBP pathway is essential for the normal genesis of neurons from neural precursors and that metformin activates this pathway to promote rodent and human neurogenesis in culture. Metformin also enhances neurogenesis in the adult mouse brain in a CBP-dependent fashion, and in so doing enhances spatial reversal learning in the water maze. Thus, metformin, by activating an aPKC-CBP pathway, recruits neural stem cells and enhances neural function, thereby providing a candidate pharmacological approach for nervous system therapy.
Although endogenous recruitment of adult neural stem cells has been proposed as a therapeutic strategy, clinical approaches for achieving this are lacking. Here, we show that metformin, a widely used drug, promotes neurogenesis and enhances spatial memory formation. Specifically, we show that an atypical PKC-CBP pathway is essential for the normal genesis of neurons from neural precursors and that metformin activates this pathway to promote rodent and human neurogenesis in culture. Metformin also enhances neurogenesis in the adult mouse brain in a CBP-dependent fashion, and in so doing enhances spatial reversal learning in the water maze. Thus, metformin, by activating an aPKC-CBP pathway, recruits neural stem cells and enhances neural function, thereby providing a candidate pharmacological approach for nervous system therapy.
Provided by Cell Press
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