A
team of researchers at Brigham and Women's Hospital, the University of
Pittsburgh Graduate School of Public Health and other institutions, have
discovered that measuring HDL particles as opposed to HDL cholesterol is a much
better indicator of coronary heart disease.
Until recently, it seemed well-established that
high-density lipoprotein (HDL) is the "good cholesterol".
However there are many unanswered questions on whether raising someone's HDL
can prevent coronary
heart disease, and on whether or not HDL still matters.
A team of researchers at Brigham and Women's Hospital
(BWH), the University of Pittsburgh Graduate School of Public Health (GSPH) and
other institutions, have discovered that measuring HDL particles (HDL-P) as
opposed to HDL cholesterol (HDL-C) is a much better indicator of coronary heart
disease (CHD), and that HDL does indeed, still matter.
This study will be electronically published July 11,
2012 and will be published in the August 7th print issue of the Journal
of American College of Cardiology.
"Several recent failures of HDL-raising drugs and
a genetic study have generated doubt that circulating levels of HDL in the
blood are causally related to heart disease, and that
raising HDL is a promising therapeutic approach,"
said Rachel Mackey, PhD, principal investigator of the study and assistant
professor of epidemiology at GSPH.
Most previous studies of HDL have looked at the
cholesterol to assess CHD risk, not many have examined the particle count. The
research team analyzed data from the Multi-Ethnic Study of Atherosclerosis (MESA),
an NIH funded multiethnic study.
The researchers focused on a subset of data of 5,500
middle-aged men and women, over the age of 45. They looked at the quantity of
HDL particles (HDL-P) in addition to the quantity of cholesterol carried by the
particles (HDL-C), which has historically been used to measure HDL.
"HDL cholesterol is only one property of HDL
particles -- it's like cargo on a ship, one can look at HDL cholesterol, which
is one type of the cargo that is carried on the ship, or one can look at the
number of ships. In our study, we found that the number of HDL particles had
stronger cardio-protection than HDL cholesterol," explained Samia Mora,
MD, a physician in the Cardiovascular and Preventive Divisions at BWH and
senior author on the study.
The study suggests that it's important to not only
measure HDL cholesterol, but to experiment with other ways of measurement, such
as HDL particles. "Before we lose confidence in the potential of raising
HDL to benefit patients, there needs to be more research extending beyond HDL cholesterol measurement,"
Explained Dr. Mackey.
Provided by Brigham
and Women's Hospital
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