Australian scientists have confirmed a 'weak link' in the immune system
– identifying the exact conditions under which an infection can trigger an
autoantibody response, a process not clearly understood until now.
We have known for many years that autoimmune diseases such
as rheumatic fever and
Guillain-Barré syndrome (where the body makes antibodies that attack the heart
and peripheral nerves respectively)
can occur after the body makes immune responses against certain infectious
micro-organisms.
We have not been able to explain
exactly how such examples of infection-driven autoimmunity occur, however, nor
why our bodies seem unable to prevent them.
Our immune cells, such as the
antibody-creating B cells, go through processes when they are first formed that
ensure they are able to identify our own bodies, and therefore avoid
self-attack. These processes are generally reliable as they take place in a
steady, regulated way.
B cells go through a second and
much more chaotic phase of development, however, when the body is fending off
disease or infection. In order to cope with the immeasurable range of microbes
in our environment, B cells have evolved the ability to mutate their antibody
genes randomly until they produce one that sticks strongly to the invader. At
that point, the 'successful' B cells proliferate and flood the system with
these new antibodies.
This 'high affinity antibody'
generation occurs very rapidly within specialised environments in the lymph system known as
'germinal centres'. Most of the time, germinal centres serve us well, helping
us fight disease and build up a protective armory for the future.
Unfortunately, the urgency and
speed at which B cells mutate within the germinal centre, as well as the random
nature of the process, creates a unique problem. Sometimes the antibody created
to fight the invader, or 'antigen', also happens to match 'self' and has the
potential to cause autoimmune
attack.
Dr Tyani Chan and Associate
Professor Robert Brink from Sydney's Garvan Institute of Medical Research
developed sophisticated mouse models to investigate when and how this happens.
They demonstrated that when antigen is abundant and generally available
throughout the body, rogue autoantibody-generating B cells are deleted and
autoimmunity avoided. Conversely, when target antigen is located only in a
tissue or organ remote from the germinal centre, B cells capable of reacting
against both antigen and 'self' are able to escape the germinal centre and
produce autoantibodies. Their finding is published in the prestigious
international journal Immunity.
"Essentially we've shown
there's a big hole in self-tolerance when it comes to cross-reactive
autoantibodies that can attack organ-specific targets," said Brink.
"Our finding explains a lot
about how autoimmune conditions that target particular organs such as the heart
or nervous system could develop after an infection. It also suggests that if
you know enough about the disease and the molecular messaging systems involved,
it may be possible in future to modulate the germinal centre response."
The team will continue to use
their new mouse model to study the various molecular reactions involved in the
progression of an autoimmune response.
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