Showing posts with label Oncology. Show all posts
Showing posts with label Oncology. Show all posts

Friday, April 29, 2016

Belarus - Test finds Chernobyl residue in Belarus milk

GUBAREVICHI: On the edge of Belarus’ Chernobyl exclusion zone, down the road from the signs warning “Stop! Radiation,” a dairy farmer offers his visitors a glass of freshly drawn milk.

Associated Press reporters politely decline the drink but pass on a bottled sample to a laboratory, which confirms it contains levels of a radioactive isotope at levels 10 times higher than the nation’s food safety limits.

That finding on the eve of the 30th anniversary of the world’s worst nuclear accident indicates how fallout from the April 26, 1986, explosion at the plant in neighboring Ukraine continues to taint life in Belarus.

The authoritarian government of this agriculture-dependent nation appears determined to restore long-idle land to farm use — and in a country where dissent is quashed, any objection to the policy is thin.

The farmer, Nikolai Chubenok, proudly says his herd of 50 dairy cows produces up to two tons of milk a day for the local factory of Milkavita, whose brand of Parmesan cheese is sold chiefly in Russia.

Milkavita officials called the AP-commissioned lab finding “impossible,” insisting their own tests show their milk supply contains traces of radioactive isotopes well below safety limits. Yet a tour along the edge of the Polesie Radioecological Reserve, a 2,200-square-kilometer (850-square-mile) ghost landscape of 470 evacuated villages and towns, reveals a nation showing little regard for the potentially cancer-causing isotopes still to be found in the soil.

Farmers suggest the lack of mutations and other glaring health problems mean Chernobyl’s troubles can be consigned to history. “There is no danger. How can you be afraid of radiation?” said Chubenok, who since 2014 has produced milk from his farm just 45 kilometers (28 miles) north of the shuttered Chernobyl site, and two kilometers (a mile) from the boundary of a zone that remains officially off-limits to full-time human habitation.

Chubenok says he hopes to double his herd size and start producing farmhouse cheese on site. His milk is part of the Milkavita supply chain for making Polesskiye brand cheese, about 90 percent of which is sold in Russia, the rest domestically. The World Bank identifies Russia as the major market for Belarusian food exports, which represent 15 percent of the country’s export economy.

Since rising to power in 1994, President Alexander Lukashenko — the former director of a state-owned farm — has stopped resettlement programs for people living near the mandatory exclusion zone and developed a long-term plan to raze empty villages and reclaim the land for crops and livestock.

The Chernobyl explosion meant 138,000 Belarusians closest to the plant had to be resettled, while 200,000 others living nearby left voluntarily. One of the most prominent medical critics of the government’s approach to safeguarding the public from Chernobyl fallout,

Dr. Yuri Bandazhevsky, was removed as director of a Belarusian research institute and imprisoned in 2001 on corruption charges that international rights groups branded politically motivated. Since his 2005 parole he has resumed his research into Chernobyl-related cancers with European Union sponsorship.

Bandazhevsky, now based in Ukraine, says he has no doubt that Belarus is failing to protect citizens from carcinogens in the food supply.

“We have a disaster,” he told the AP in the Ukraine capital, Kiev. “In Belarus, there is no protection of the population from radiation exposure. On the contrary, the government is trying to persuade people not to pay attention to radiation, and food is grown in contaminated areas and sent to all points in the country.”

The milk sample subjected to an AP-commissioned analysis backs this picture.

The state-run Minsk Center of Hygiene and Epidemiology said it found strontium-90, a radioactive isotope linked to cancers and cardiovascular disease, in quantities 10 times higher than Belarusian food safety regulations allow.

The test, like others in resource-strapped Belarus, was insufficiently sophisticated to test for heavier radioactive isotopes associated with nuclear fallout, including americium and variants of plutonium.



The Belarusian Agriculture Ministry says levels of strontium-90 should not exceed 3.7 becquerels per kilogram in food and drink. Becquerels are a globally recognized unit of measurement for radioactivity.

The Minsk lab informed the AP that the milk sample contained 37.5 becquerels. That radioactive isotope is, along with cesium-137, commonly produced during nuclear fission and generates most of the heat and penetrating radiation from nuclear waste. When consumed, scientists say strontium-90 mimics the behavior of calcium in the human body, settling in bones.

Milkavita chief engineer Maia Fedonchuk rejected the findings. “It’s impossible. We do our own testing.

There must have been a mix-up,” she said, adding they test samples from every batch of milk they receive from Chubenok and do an “in-depth” analysis every six months. She said the plant’s own lab analysis indicates its overall milk supply contains an average of 2.85 becquerels per kilogram.

Health officials say the danger level posed by low levels of radioactive isotopes depends greatly on length of exposure and individual physiology. Notably, the regional free-trade bloc that includes Belarus and Russia permits higher levels of strontium-90 in goods of up to 25 becquerels per kilogram, still lower than that detected in the AP-commissioned test.

The question is whether anyone in authority is positioned to identify the true level of risks in produce from farms on the frontier of Belarus’ prohibited zone.

The deputy director of Belarus’ Institute of Radiobiology, Natalya Timokhina, said Belarus permits food producers to conduct their own food safety monitoring and lacks the lab equipment necessary to identify the presence of americium, which is estimated to be present in about 2 percent of Belarus’ top soil and is expected to remain a health risk for another 270 years.

“One-time ingestion of contaminated food is not very dangerous,” Timokhina said. “What’s dangerous is the accumulation of radionuclides in the body.”

Ausrele Kesminiene, a doctor in the cancer research unit of the World Health Organization, said the consumption of radioactive food is linked chiefly to the development of cancer in the thyroid, a gland in the neck that produces body-regulating hormones.

Thyroid cancer is typically not fatal if diagnosed early. WHO officials say they are dependent on reports from sister agencies in Belarus to alert them to cancer clusters or other signs of unresolved Chernobyl-related dangers.

Gregory Hartl, a WHO spokesman in Geneva, said the agency had no authority to regulate or oversee food safety — even products exported to other countries — because that is a domestic responsibility.

“Radiation effects and the development of cancers and the effects on the region are something which go on over a long, long period. So we haven’t seen the end of it,” Hartl said.

“Undoubtedly there is going to be some increase in cancers.” Hartl said WHO officials have not received “any red flags” from Belarus.

Environmentalists critical of Belarus’ Chernobyl cleanup record says that’s hardly surprising, since the government has funded no machinery to scrutinize corrupt practices in the food industry.

As a result, they say, no Belarusian food maker has ever been prosecuted for using ingredients or producing goods containing excessive levels of radioactive materials. Irina Sukhiy, founder of the Belarus ecological group Green Network, said workers in food-industry factories have confidentially told her that ingredients and products are blended to dilute the impact of potentially radioactive ingredients from Belarusian suppliers bordering Ukraine.

Such alleged mixing, she said, reduces the level of potentially carcinogenic isotopes in dairy products and processed meat below “the allowable dose, but it is still hazardous to health.” The division of the Belarusian Emergencies Ministry responsible for cleaning up the consequences of Chernobyl says that the rate of thyroid cancer in children runs 33 times higher than before the nuclear blast.

It says thyroid cancer rates run several times higher in adults. Farmers working both on the edge of, and inside, the prohibited zone say they see no obvious signs of nuclear dangers, have been given no guidelines on reducing the risk of permitting radioactive isotopes into the food chain, and aren’t worried about this.

Chubenok, the dairy farmer, said he had never heard of the sorbent substance Ferocin, known as Prussian Blue, which farmers in Ukraine feed their cattle to accelerate the removal of the cesium-137 isotope from their digestive tracts.

A tractor driver on one of his neighboring farms, where an abandoned village has been demolished to make way for fields of grain, says he’s never seen an official testing for radiation levels in the soil.

But Leonid Kravchenko said there was no reason for alarm. “Nobody’s in danger,” he said. Driving toward Chernobyl and into the nearby Radioecological Reserve required AP journalists to negotiate painstaking government permission.

Inside the zone, Belarus has authorized an experimental farm to operate for the past decade. Today it contains 265 horses, 56 cows and apiaries buzzing with honey bees.

The farm director, Mikhail Kirpichenko, said he’s permitted to pursue commercial ventures, including the sale last year of 100 horses to a Belarusian manufacturer of kumys, a popular beverage in swathes of Eastern Europe and Central Asia.

Kumys is produced from fermented mares’ milk. “We’re not afraid of radiation. We’ve already gotten used to it,” said Kirpichenko, who suggested that his horses had to pass a basic eyesight test to confirm their good health. “Horses aren’t being born with two heads or without legs. There are no such mutations,” he said. “This Chernobyl syndrome passed long ago.”

AP


Malaysia - Rice and rice products may expose infants to arsenic

Rice grains can take up arsenic from their environment, and US rice has some of the highest arsenic concentrations in the world.

Infant rice cereal and rice snacks contain some arsenic, and babies who eat these products have higher levels of arsenic in their urine, a study shows.

It’s not clear yet whether the arsenic will affect their health down the line.

“We knew rice cereal was a typical first food for babies – but we knew very little about how common it is to feed infants rice cereal in the US, or about the timing of introduction of rice cereal,” said lead author Margaret Karagas, of the Geisel School of Medicine at Dartmouth College in Hanover, New Hampshire.

Rice grains can take up arsenic from their environment, and US rice has some of the highest arsenic concentrations in the world, she said.

“Arsenic is a known carcinogen that can influence risk of cardiovascular, immune and other diseases,” Karagas told Reuters Health by email. “There’s a growing body of evidence that even relatively low levels of exposure may have adverse health impacts on young children including on growth, immunity and neurodevelopment.”

She and her team are still investigating whether the infants in this study had any health effects due to arsenic exposure, she said.

The researchers studied 759 infants born to mothers age 18 to 45. Parents reported their infant’s intake of rice products like rice cakes or puffs or dried breakfast cereals containing rice, or brands of cereal bars sweetened with brown rice syrup, in interviews when the baby was four, eight and 12 months of age. The researchers also collected infant urine samples to test for arsenic levels.

About 80 percent of the children were introduced to rice cereal before age one, and a third were eating rice snacks by their first birthday.

Among kids who did not eat fish or seafood, urinary arsenic concentrations were higher for those who ate infant rice cereal or snacks than for those who did not, according to results in JAMA Pediatrics.

The researchers also tested for arsenic levels in some of the more commonly reported rice snacks.

“We were surprised by the percentage of infants who ate rice snacks and that one of these products contained levels above the current EU standard of 100 parts per billion,” Karagas said. “This was a strawberry flavored puffed rice snack, which contained 40 percent inorganic arsenic, with the first two ingredients listed as brown and white rice flour.”

Inorganic arsenic exposure has been linked to cancer as well as other health problems such as neurological, cardiovascular, respiratory and metabolic diseases, said Dr. Antonio J. Signes-Pastor, of the Institute for Global Food Security at Queen’s University Belfast in Northern Ireland.

“This is of particular concern for young children, who are more sensitive to adverse health effects of inorganic arsenic and consume higher amount of inorganic arsenic from food compared to adults per kilogram of body weight,” said Signes-Pastor, who was not part of the new study.

It is important, he said in an email, “to reduce exposure by establishing maximum limits of inorganic arsenic in rice and rice-based products.”

The US Food and Drug Administration had proposed a limit for inorganic arsenic in infant rice cereal of 100 parts per billion, which would mimic the current limit in the European Union, Karagas said.

Reuters


Sunday, January 27, 2013

Singapore - Scientists step up fight against cancer with new oncology network


SINGAPORE: Scientists from various disciplines are coming together to tackle the prevalence of cancer in Asia -- by working on novel therapies and translating research ideas to the clinic faster.

They will do so under the Integrated Translational Oncology Network, which was launched on Wednesday by Bayer HealthCare.

The research partners include the National University of Singapore, National Cancer Centre Singapore and the Agency for Science, Technology and Research (A*STAR).

Through the network, scientists will discuss their research projects at different phases.

They will share their strategic vision, as well as jointly develop and evaluate novel treatment options in projects and trials.

They will also organise activities, such as annual meetings, workshops and lectures, and link their network and activities to other leading centres in Asia.

-CNA/ac

Friday, June 22, 2012

Singapore - Oncology: Understanding the culprit


Study using a systems biology approach reveals how the transcription factor EVI1 contributes to cancer development and tumor invasion

Since its discovery close to 25 years ago, the EVI1 gene has emerged as a major player in many different types of cancer, including leukemia and tumors of the breast, prostate and colon, among other organs. In the US, for example, there is a company called NanoOncology that was founded to develop drugs for blocking this oncogene. Yet, despite all the interest in EVI1, very few of the gene’s downstream targets are known.

Emilie Bard-Chapeau at the A*STAR Institute of Molecular and Cell Biology and co-workers1 have now used a systems biology approach to identify a slew of tumor-associated genes that are controlled by EVI1. The discovery could lead to new therapeutic drug strategies to combat various forms of cancer.

The EVI1 gene — short for ‘ecotropic viral integration site 1’ — encodes a zinc-finger transcription factor with two distinct DNA binding domains. When overexpressed, this oncogene leads to aggressive forms of cancer and poor patient survival. To better understand the biochemical functions of EVI1, Bard-Chapeau and co-workers searched for gene promoters and cooperating transcription factors that are actively bound by EVI1 in human ovarian cancer and chronic myeloid leukemia cell lines.

Systems biology uses a palette of analytical and computational techniques to study the complex interactions in biological systems. Using microarrays, ChIP-sequencing and immunoprecipitation assays, the researchers found that the two different zinc-finger domains of EVI1 activate unique sets of target genes, many of which are involved in cell adhesion, proliferation, colony formation and other aspects of tumor growth.

Notably, the researchers documented a strong association between EVI1 and FOS — the latter being one of the main components of the activator protein 1 (AP1) transcription factor complex that is known to drive tumorigenesis. Experiments in cell lines showed that EVI1 and FOS interact to co-regulate many hallmarks of cancer, and follow-up analyses in late-stage ovarian cancers taken from patients revealed an enrichment in expressed genes linked to both EVI1 and AP1. Taken together, the findings suggest that EVI1 expression might serve to fully elicit FOS oncogenic potential through a feed-forward regulatory loop that drives abnormal tissue changes.

“Our study has provided new mechanistic insights into the regulatory mechanism of EVI1, and revealed how EVI1 can function as a central player in many types of late-stage cancers,” says Bard-Chapeau. “Disruption of the interaction between EVI1 and FOS may be a very interesting way to prevent cancer progression.”

The A*STAR-affiliated researchers contributing to this research are from the Institute of Molecular and Cell Biology, the Genome Institute of Singapore and the Bioinformatics Institute

References
  1. Bard-Chapeau, E. A. et al. Ecotopic viral integration site 1 (EVI1) regulates multiple cellular processes important for cancer and is a synergistic partner for FOS protein in invasive tumors. Proceedings of the National Academy of Sciences USA 109, 2168–2173 (2012). | article